Identification of three new Ig lambda-like genes in man.
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Chang H, Dmitrovsky E, Hieter PA, Mitchell K, Leder P, Turoczi L, Kirsch IR, Hollis GF
Identification of three new Ig lambda-like genes in man.
J Exp Med. 1986 Feb 1;163(2):425-35.
- PubMed ID
- 3003227 [ View in PubMed]
- Abstract
Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.