Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.
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Wolff KA, Nguyen HT, Cartabuke RH, Singh A, Ogwang S, Nguyen L
Protein kinase G is required for intrinsic antibiotic resistance in mycobacteria.
Antimicrob Agents Chemother. 2009 Aug;53(8):3515-9. doi: 10.1128/AAC.00012-09. Epub 2009 Jun 15.
- PubMed ID
- 19528288 [ View in PubMed]
- Abstract
Antibiotic resistance and virulence of pathogenic mycobacteria are phenotypically associated, but the underlying genetic linkage has not been known. Here we show that PknG, a eukaryotic-type protein kinase previously found to support survival of mycobacteria in host cells, is required for the intrinsic resistance of mycobacterial species to multiple antibiotics.