Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis.

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Nudel DB, Peterson BJ, Buckley BJ, Kaplan NA, Weinhaouse E, Gootman N

Comparative effects of bicarbonate and dichloroacetate in newborn swine with hypoxic lactic acidosis.

Dev Pharmacol Ther. 1990;15(2):86-93.

PubMed ID

1964114 [ View in PubMed

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Abstract

Sodium bicarbonate (BC) and dichloroacetate (DCA) were studied in 7- to 14-day-old (n = 25) anesthetized swine with hypoxic acidosis. BC (base deficit X kg X 0.3, n = 10), DCA (300 mg/kg, n = 7) or saline (n = 8) was infused for 1 h. Blood lactic acid, dP/dtmax, heart rate and cardiac output increased and base excess and total arterial and carotid resistances (R) decreased with acidosis; aortic pressure, renal and mesenteric R did not change. BC induced higher pH, base excess and lactic acid. Heart rate in all and dP/dtmax with BC and DCA were restored; renal and mesenteric R and aortic pressure decreased in all. Cardiovascular responses to DCA and BC did not differ except for renal R. CONCLUSION: BC is a more effective alkalizer than DCA, which induced a greater renal vasodilation; both restored contractility.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Sodium bicarbonate	Hydrogen ions	Small molecule		Yes	Neutralizer	Details