Studies of interactions between uracil-based hybrid molecules and P-glycoprotein--search for multidrug resistance modulators.
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Singh P, Paul K
Studies of interactions between uracil-based hybrid molecules and P-glycoprotein--search for multidrug resistance modulators.
Bioorg Med Chem. 2006 Nov 1;14(21):7183-6. Epub 2006 Jul 14.
- PubMed ID
- 16843673 [ View in PubMed]
- Abstract
The hybrid molecules having structural features of anticancer drug, 5-fluorouracil, and MDR modulator, propafenone, have been studied for their interactions with P-glycoprotein (P-gp). Some of the molecules (5, 8, and 9) show considerable interactions with P-gp and could be the potential candidates for their in vivo evaluation as MDR modulators. Further investigations show the dependence of P-gp interacting properties of these compounds on their physico-chemical parameters like logP and total polar surface area.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Propafenone P-glycoprotein 1 Protein Humans UnknownInhibitorDetails