Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor.

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Quadros EV, Sequeira JM

Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor.

Biochimie. 2013 May;95(5):1008-18. doi: 10.1016/j.biochi.2013.02.004. Epub 2013 Feb 14.

PubMed ID
23415653 [ View in PubMed
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Abstract

Cellular uptake of cobalamin is facilitated by a receptor-mediated endocytosis process involving transcobalamin, a plasma protein that binds cobalamin and a cell surface receptor that specifically binds transcobalamin saturated with cobalamin. Intracellular Cbl concentration is maintained by modulating the expression of the receptor, which is cell cycle associated with highest expression in actively proliferating cells and an efflux system that shunts the excess cobalamin out of the cells for mobilization to other tissues where it is most needed. This review describes the process, proteins involved and genes encoding these proteins.

DrugBank Data that Cites this Article

Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
CyanocobalaminMultidrug resistance-associated protein 1ProteinHumans
Unknown
Not AvailableDetails