The L-type calcium channel in the heart: the beat goes on.

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Bodi I, Mikala G, Koch SE, Akhter SA, Schwartz A

The L-type calcium channel in the heart: the beat goes on.

J Clin Invest. 2005 Dec;115(12):3306-17. doi: 10.1172/JCI27167.

PubMed ID

16322774 [ View in PubMed

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Abstract

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Amlodipine	Voltage-dependent L-type calcium channel subunit alpha-1C	Protein	Humans	Yes	Inhibitor	Details