Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases.
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Bonomo RA, Rudin SA, Shlaes DM
Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases.
FEMS Microbiol Lett. 1997 Mar 1;148(1):59-62. doi: 10.1111/j.1574-6968.1997.tb10267.x.
- PubMed ID
- 9066111 [ View in PubMed]
- Abstract
The beta-lactam beta-lactamase inhibitor combinations (ampicillin/clavulanate, ampicillin/sulbactam, ticarcillin/clavulanate and piperacillin/tazobactam) were tested against selected inhibitor-resistant class A beta-lactamases of the TEM and OHIO-1 varieties. Minimum inhibitor concentrations (MIC) revealed that the Escherichia coli DH5 alpha transconjugate strains that possessed the OHIO-1 beta-lactamase, Met69Ile mutant of the OHIO-1 beta-lactamase, TEM-30 (Arg244Ser) and TEM-31 (Arg244Cys) beta-lactamase were most susceptible to piperacillin and piperacillin/tazobactam. Kinetic experiments with each beta-lactamase demonstrated that tazobactam was 10-25-fold more potent than clavulanate or sulbactam against TEM-30 and TEM-31 beta-lactamase. Tazobactam was also as effective as clavulanate against the Met69Ile mutant of the OHIO-1 beta-lactamase. Among the clinically available beta-lactams and beta-lactamase inhibitors, piperacillin/tazobactam appears to be the most potent combination against selected inhibitor-resistant strains of TEM and OHIO-1 beta-lactamase.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tazobactam Beta-lactamase Ohio-1 Protein Enterobacter cloacae YesInhibitorDetails Tazobactam Beta-lactamase SHV-1 Protein Escherichia coli YesInhibitorDetails Tazobactam Beta-lactamase TEM Protein Salmonella typhi YesInhibitorDetails