The 5'-nucleotidases as regulators of nucleotide and drug metabolism.
Article Details
- CitationCopy to clipboard
Hunsucker SA, Mitchell BS, Spychala J
The 5'-nucleotidases as regulators of nucleotide and drug metabolism.
Pharmacol Ther. 2005 Jul;107(1):1-30.
- PubMed ID
- 15963349 [ View in PubMed]
- Abstract
The 5'-nucleotidases are a family of enzymes that catalyze the dephosphorylation of nucleoside monophosphates and regulate cellular nucleotide and nucleoside levels. While the nucleoside kinases responsible for the initial phosphorylation of salvaged nucleosides have been well studied, many of the catabolic nucleotidases have only recently been cloned and characterized. Aside from maintaining balanced ribo- and deoxyribonucleotide pools, substrate cycles that are formed with kinase and nucleotidase activities are also likely to regulate the activation of nucleoside analogues, a class of anticancer and antiviral agents that rely on the nucleoside kinases for phosphorylation to their active forms. Both clinical and in vitro studies suggest that an increase in nucleotidase activity can inhibit nucleoside analogue activation and result in drug resistance. The physiological role of the 5'-nucleotidases will be covered in this review, as will the evidence that these enzymes can mediate resistance to nucleoside analogues.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Lamivudine 5'(3')-deoxyribonucleotidase, cytosolic type Protein Humans UnknownSubstrateDetails Lamivudine Deoxycytidine kinase Protein Humans UnknownSubstrateDetails Lamivudine Nucleoside diphosphate kinase A Protein Humans UnknownSubstrateDetails Lamivudine Nucleoside diphosphate kinase B Protein Humans UnknownSubstrateDetails Lamivudine Phosphoglycerate kinase 1 Protein Humans UnknownSubstrateDetails Lamivudine UMP-CMP kinase Protein Humans UnknownSubstrateDetails