Role of transporters in the disposition of a novel beta-lactamase inhibitor: relebactam (MK-7655).
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Chan G, Houle R, Lin M, Yabut J, Cox K, Wu J, Chu X
Role of transporters in the disposition of a novel beta-lactamase inhibitor: relebactam (MK-7655).
J Antimicrob Chemother. 2019 Jul 1;74(7):1894-1903. doi: 10.1093/jac/dkz101.
- PubMed ID
- 30891606 [ View in PubMed]
- Abstract
OBJECTIVES: To identify the transporters involved in renal elimination of relebactam, and to assess the potential of relebactam as a perpetrator or victim of drug-drug interactions (DDIs) for major drug transporters. METHODS: A series of bidirectional transport, uptake and inhibition studies were conducted in vitro using transfected cell lines and membrane vesicles. The inhibitory effects of relebactam on major drug transporters, as well as the inhibitory effects of commonly used antibiotics/antifungals on organic anion transporter (OAT) 3-mediated uptake of relebactam, were assessed. RESULTS: Relebactam was shown to be a substrate of OAT3, OAT4, and multidrug and toxin extrusion (MATE) proteins MATE1 and MATE2K. Relebactam did not show profound inhibition across a panel of transporters, including organic anion-transporting polypeptides 1B1 and 1B3, OAT1, OAT3, organic cation transporter 2, MATE1, MATE2K, breast cancer resistance protein, multidrug resistance protein 1 and the bile salt export pump. Among the antibiotics/antifungals assessed for potential DDIs, probenecid demonstrated the most potent in vitro inhibition of relebactam uptake; however, such in vitro data did not translate into clinically relevant DDIs, suggesting that relebactam can be co-administered with OAT inhibitors, such as probenecid. CONCLUSIONS: Overall, relebactam has low potential to be a victim or perpetrator of DDIs with major drug transporters.
DrugBank Data that Cites this Article
- Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Relebactam Multidrug and toxin extrusion protein 1 Protein Humans UnknownSubstrateDetails Relebactam Multidrug and toxin extrusion protein 2 Protein Humans UnknownSubstrateDetails Relebactam Solute carrier family 22 member 11 Protein Humans UnknownSubstrateDetails Relebactam Solute carrier family 22 member 8 Protein Humans UnknownSubstrateDetails