Multiple serotonin receptors: clinical and experimental aspects.
Article Details
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Roth BL
Multiple serotonin receptors: clinical and experimental aspects.
Ann Clin Psychiatry. 1994 Jun;6(2):67-78.
- PubMed ID
- 7804391 [ View in PubMed]
- Abstract
Serotonin (5-hydroxytryptamine; 5-HT) has been implicated in a large number of psychophysiologic processes including the regulation of sleep, appetite, mood, aggression, perception, memory, and anxiety. To mediate this large array of physiologic processes, at least 14 separate 5-HT receptors have evolved, which are divided into seven main families. Not surprisingly, alterations of 5-HT receptor activity have been shown to occur in many psychiatric diseases including anxiety, depression, eating disorders, schizophrenia, personality disorders, and many drug-induced psychotic states. Additionally, a number of effective psychopharmacologic agents for diseases as diverse as schizophrenia and anxiety have been developed which either specifically alter brain levels of serotonin or bind to 5-HT receptor subtypes. This review article summarizes recent advances in the burgeoning field of serotonin receptor pharmacology and integrates this information into a coherent perspective on the importance of serotonergic agents for clinical psychiatry.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Imipramine 5-hydroxytryptamine receptor 2C Protein Humans UnknownAntagonistBinderDetails Imipramine 5-hydroxytryptamine receptor 6 Protein Humans UnknownBinderDetails Imipramine 5-hydroxytryptamine receptor 7 Protein Humans UnknownAntagonistDetails