Activation of human pepsinogens.
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Foltmann B
Activation of human pepsinogens.
FEBS Lett. 1988 Dec 5;241(1-2):69-72. doi: 10.1016/0014-5793(88)81033-0.
- PubMed ID
- 3197840 [ View in PubMed]
- Abstract
Human pepsinogen A3 and A5 have been purified to chromatographic and electrophoretic homogeneity. At pH 2 pepsinogen A3 activates at a much faster rate than pepsinogen A5. Leu-23-Lys-24 is the first bond cleaved during activation of pepsinogen A3. This bond is also cleaved in pepsinogen A5, but together with the cleavage of Asp-25-Phe-26. Amino acid sequencing shows that pepsinogen A3 has Glu at position 43, whereas pepsinogen A5 has Lys.