The plasma protein binding of metoclopramide in health and renal disease.
Article Details
- CitationCopy to clipboard
Webb D, Buss DC, Fifield R, Bateman DN, Routledge PA
The plasma protein binding of metoclopramide in health and renal disease.
Br J Clin Pharmacol. 1986 Mar;21(3):334-6. doi: 10.1111/j.1365-2125.1986.tb05201.x.
- PubMed ID
- 3964535 [ View in PubMed]
- Abstract
The plasma protein binding of metoclopramide was measured after addition of the drug (60 ng ml-1) to plasma from 18 patients with renal disease and 18 age and sex matched healthy individuals. The mean free fraction in renal disease (0.59 range 0.41-0.71) was not significantly different from controls (mean 0.6 range 0.56-0.69). In both groups the binding ratio of metoclopramide was significantly related to plasma alpha 1-acid glycoprotein (AAG) concentration but not to albumin or plasma non-esterified fatty acids concentration. Metoclopramide bound to human serum albumin (HSA) to a limited extent and to human AAG to a greater extent indicating that AAG is the major binding protein for the drug in plasma.
DrugBank Data that Cites this Article
- Drugs
- Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Metoclopramide Alpha-1-acid glycoprotein 1 Protein Humans UnknownBinderDetails