Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease.

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Norman T, Chiu E, James RH, Gregory MS

Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease.

Eur J Clin Pharmacol. 1987;32(6):583-6.

PubMed ID
2958291 [ View in PubMed
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Abstract

The pharmacokinetic properties of a single oral dose of 100 mg of tiapride were studied in six patients with Huntington's disease. The results for five patients were consistent with a two compartment open model. Peak plasma concentrations were observed within 2 h following drug administration with a mean value of 0.92 micrograms/ml being recorded. The drug was rapidly eliminated as unmetabolised tiapride in the urine, 51% of the dose was recovered in 24 h. The plasma elimination half-life was 5.3 h and the average apparent plasma clearance was 16.6 l/h.

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