Tiapride is a dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism.
- Mechanism
- Curator reviewed
Tiapride is a selective dopamine D2 and D3 receptor antagonist, offering an advantage over other neuroleptic drugs, such as haloperidol and risperidone, which bind a range of targets including four of the five known dopamine receptor subtypes (D1-4), serotonin (5-HT2A, 2C), α1- and α2-adrenergic, and histamine H1 receptors. Compared to these drugs, tiapride has a relatively moderate affinity for its target receptors, displacing 50 percent of 3H-raclopride binding at a concentration of 320 nM at D2 receptors and a concentration of 180 nM at D3 receptors.
- Primary indication
- Tiapride is indicated for the treatment of a variety of neurological and psychiatric disorders including dyskinesia, alcohol withdrawal syndrome, negative symptoms of psychosis, and agitation and aggression in the elderly.Curator reviewed · 3 structured indications
- Formula / weight
- C15H24N2O4S · 328.427 g/mol (avg)
- Also known as
- Thiapride
- Code names
- FLO 1347
Resolves to
JTVPZMFULRWINT-UHFFFAOYSA-NSMILESCCN(CC)CCNC(=O)C1=CC(=CC=C1OC)S(C)(=O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Tiapride, and which of those have an active Phase 3 trial?
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