In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria.
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Ito A, Sato T, Ota M, Takemura M, Nishikawa T, Toba S, Kohira N, Miyagawa S, Ishibashi N, Matsumoto S, Nakamura R, Tsuji M, Yamano Y
In Vitro Antibacterial Properties of Cefiderocol, a Novel Siderophore Cephalosporin, against Gram-Negative Bacteria.
Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: AAC.01454-17. doi: 10.1128/AAC.01454-17. Print 2018 Jan.
- PubMed ID
- 29061741 [ View in PubMed]
- Abstract
Cefiderocol (CFDC; S-649266), a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, including carbapenem-resistant strains of Enterobacteriaceae and nonfermenting bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii Cefiderocol has affinity mainly for penicillin-binding protein 3 (PBP3) of Enterobacteriaceae and nonfermenting bacteria similar to that of ceftazidime. A deficiency of the iron transporter PiuA in P. aeruginosa or both CirA and Fiu in Escherichia coli caused 16-fold increases in cefiderocol MICs, suggesting that these iron transporters contribute to the permeation of cefiderocol across the outer membrane. The deficiency of OmpK35/36 in Klebsiella pneumoniae and the overproduction of efflux pump MexA-MexB-OprM in P. aeruginosa showed no significant impact on the activity of cefiderocol.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cefiderocol D-alanyl-D-alanine carboxypeptidase DacB Protein Escherichia coli (strain K12) YesInhibitorDetails Cefiderocol Penicillin-binding protein 1A Protein Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) YesInhibitorDetails Cefiderocol Penicillin-binding protein 1B Protein Pseudomonas aeruginosa YesInhibitorDetails Cefiderocol Penicillin-binding protein 2 Protein Pseudomonas aeruginosa YesInhibitorDetails Cefiderocol Penicillin-binding protein 3 Protein Pseudomonas aeruginosa YesInhibitorDetails - Drug Transporters
Drug Transporter Kind Organism Pharmacological Action Actions Cefiderocol Catecholate siderophore receptor Fiu Protein Escherichia coli (strain K12) NoSubstrateDetails Cefiderocol Colicin I receptor Protein Escherichia coli (strain K12) NoSubstrateDetails Cefiderocol MexAB-OprM efflux system (Protein Group) Protein group Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) NoSubstrateDetails Cefiderocol Putative outer membrane ferric siderophore receptor Protein Pseudomonas aeruginosa (strain UCBPP-PA14) NoSubstrateDetails