Identification of the serum binding proteins for iron, zinc, cadmium, nickel, and calcium.

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Scott BJ, Bradwell AR

Identification of the serum binding proteins for iron, zinc, cadmium, nickel, and calcium.

Clin Chem. 1983 Apr;29(4):629-33.

PubMed ID

6831689 [ View in PubMed

]

Abstract

The binding of five biologically important metals to serum proteins has been studied. After suitable radioactive isotopes were added to serum proteins separated and precipitated by two-dimensional immunoelectrophoresis, the sample plates were exposed to roentgenogram film. 59Fe bound to transferrin alone; 65Zn bound mostly to albumin, but also to another 12 proteins; 109Cd was mostly associated with alpha 2-macroglobulin, but was also present on albumin, immunoglobulins G and A, and prealbumin; 63Ni, added in high concentration, was associated with an alpha 2-mobility protein and albumin; and, finally, 45Ca was mostly bound to albumin, but seven other binding proteins were also identified, with transferrin predominant. The results are not quantitative, but the technique is simple and specific, and the information gained can direct further studies on isolated proteins.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Zinc chloride	Serum albumin	Protein	Humans	Unknown	Binder	Details
Zinc sulfate, unspecified form	Serum albumin	Protein	Humans	Unknown	Binder	Details