Effects of anesthetics on mitochondrial signaling and function.

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La Monaca E, Fodale V

Effects of anesthetics on mitochondrial signaling and function.

Curr Drug Saf. 2012 Apr;7(2):126-39. doi: 10.2174/157488612802715681.

PubMed ID

22873497 [ View in PubMed

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Abstract

Mitochondria are considered the powerhouses of the cell playing an important role in energy metabolism. However, they are highly vulnerable to inhibition or uncoupling of the energy harnessing process and run a high risk of causing catastrophic damage to the cell. Several anesthetics or drugs commonly given during anesthesia interact with mitochondria and affect their structure or impair respiratory chain functioning with decreased ATP production. Mitochondria, in fact, are a potential site of action of general and local anesthetics. The purpose of this review is to update present knowledge and describe the effects and molecular mechanisms of the action of the most used drugs of anesthesia on mitochondria.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Sevoflurane	Mitochondrial potassium channel	Protein	Humans	Yes	Activator	Details
Sevoflurane	NADH-ubiquinone oxidoreductase chain 1	Protein	Humans	Unknown	Inhibitor	Details