Effects of anesthetics on mitochondrial signaling and function.

Article Details


La Monaca E, Fodale V

Effects of anesthetics on mitochondrial signaling and function.

Curr Drug Saf. 2012 Apr;7(2):126-39. doi: 10.2174/157488612802715681.

PubMed ID
22873497 [ View in PubMed

Mitochondria are considered the powerhouses of the cell playing an important role in energy metabolism. However, they are highly vulnerable to inhibition or uncoupling of the energy harnessing process and run a high risk of causing catastrophic damage to the cell. Several anesthetics or drugs commonly given during anesthesia interact with mitochondria and affect their structure or impair respiratory chain functioning with decreased ATP production. Mitochondria, in fact, are a potential site of action of general and local anesthetics. The purpose of this review is to update present knowledge and describe the effects and molecular mechanisms of the action of the most used drugs of anesthesia on mitochondria.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
SevofluraneMitochondrial potassium channelProteinHumans
SevofluraneNADH-ubiquinone oxidoreductase chain 1ProteinHumans