Hephaestin--a ferroxidase of cellular iron export.

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Petrak J, Vyoral D

Hephaestin--a ferroxidase of cellular iron export.

Int J Biochem Cell Biol. 2005 Jun;37(6):1173-8. Epub 2005 Jan 26.

PubMed ID

15778082 [ View in PubMed

]

Abstract

Hephaestin is a transmembrane copper-dependent ferroxidase necessary for effective iron transport from intestinal enterocytes into the circulation. Hephaestin is mutated in sex-linked anemia (sla) mice. The initial uptake of iron from the diet in these animals is normal, but the basolateral export of iron from enterocytes is defective, resulting in iron deficiency and microcytic hypochromic anemia. In addition to the small intestine, hephaestin is expressed to a lesser extent in colon, spleen, placenta and kidney but its role in these tissues remains unknown. So far, hephaestin has not been linked to a human disease.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Copper	Hephaestin-like protein 1	Protein	Humans	Unknown	Cofactor	Details