Regulation of protein kinase cascades by protein phosphatase 2A.

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Millward TA, Zolnierowicz S, Hemmings BA

Regulation of protein kinase cascades by protein phosphatase 2A.

Trends Biochem Sci. 1999 May;24(5):186-91. doi: 10.1016/s0968-0004(99)01375-4.

PubMed ID

10322434 [ View in PubMed

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Abstract

Many protein kinases themselves are regulated by reversible phosphorylation. Upon cell stimulation, specific kinases are transiently phosphorylated and activated. Several of these protein kinases are substrates for protein phosphatase 2A (PP2A), and PP2A appears to be the major kinase phosphatase in eukaryotic cells that downregulates activated protein kinases. This idea is substantiated by the observation that some viral proteins and naturally occurring toxins target PP2A and modulate its activity. There is increasing evidence that PP2A activity is regulated by extracellular signals and during the cell cycle. Thus, PP2A is likely to play an important role in determining the activation kinetics of protein kinase cascades.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Vitamin E	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	Protein	Humans	Unknown	Not Available	Details
Vitamin E	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform	Protein	Humans	Unknown	Not Available	Details