Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase - United States, 2010.
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Detection of Enterobacteriaceae isolates carrying metallo-beta-lactamase - United States, 2010.
MMWR Morb Mortal Wkly Rep. 2010 Jun 25;59(24):750.
- PubMed ID
- 20577157 [ View in PubMed]
- Abstract
During January-June 2010, three Enterobacteriaceae isolates carrying a newly described resistance mechanism, the New Delhi metallo-beta-lactamase (NDM-1), were identified from three U.S. states at the CDC antimicrobial susceptibility laboratory. This is the first report of NDM-1 in the United States, and the first report of metallo-beta-lactamase carriage among Enterobacteriaceae in the United States. These isolates, which include an Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, carry blaNDM-1, which confers resistance to all beta-lactam agents except aztreonam (a monobactam antimicrobial); all three isolates were aztreonam resistant, presumably by a different mechanism. In the United Kingdom, where these organisms are increasingly common, carriage of Enterobacteriaceae containing blaNDM-1 has been closely linked to receipt of medical care in India and Pakistan. All three U.S. isolates were from patients who received recent medical care in India.