Independent antibiotic actions of hetacillin and ampicillin revealed by fast methods.

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Faine S, Harper M

Independent antibiotic actions of hetacillin and ampicillin revealed by fast methods.

Antimicrob Agents Chemother. 1973 Jan;3(1):15-8. doi: 10.1128/aac.3.1.15.

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4597707 [ View in PubMed
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Abstract

Fast methods for measuring inhibition of growth of Escherichia coli or Staphylococcus aureus by hetacillin or ampicillin showed that the rate of inhibition was a function of the antibiotic concentration. When ampicillin concentrations were measured rapidly, hetacillin was shown to have a half-life of 20 min at 37 C and pH 6.7. Hetacillin was much less susceptible to penicillinase (beta-lactamase) than was ampicillin. An inhibitory effect of hetacillin was shown in the presence of beta-lactamase, which destroyed ampicillin activity very rapidly.

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