Off-the-Shelf CAR-NK Cells for Cancer Immunotherapy.

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Siegler EL, Zhu Y, Wang P, Yang L

Off-the-Shelf CAR-NK Cells for Cancer Immunotherapy.

Cell Stem Cell. 2018 Aug 2;23(2):160-161. doi: 10.1016/j.stem.2018.07.007.

PubMed ID
30075127 [ View in PubMed
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Abstract

CAR-T therapy has shown great success treating blood cancers, but drawbacks include high manufacturing costs and potentially fatal toxicities such as cytokine release syndrome. In this issue of Cell Stem Cell, Li et al. (2018) describe how engineered iPSC-derived NK cells armed with NK-tailored CAR constructs (CAR-iPSC-NK cells) provide better options for anti-cancer immunotherapy.

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