C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.
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Alvarez CP, Lasala F, Carrillo J, Muniz O, Corbi AL, Delgado R
C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.
J Virol. 2002 Jul;76(13):6841-4. doi: 10.1128/jvi.76.13.6841-6844.2002.
- PubMed ID
- 12050398 [ View in PubMed]
- Abstract
Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.