Effects of growth hormone on glucose metabolism and insulin resistance in human.

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Kim SH, Park MJ

Effects of growth hormone on glucose metabolism and insulin resistance in human.

Ann Pediatr Endocrinol Metab. 2017 Sep;22(3):145-152. doi: 10.6065/apem.2017.22.3.145. Epub 2017 Sep 28.

PubMed ID

29025199 [ View in PubMed

]

Abstract

Growth hormone (GH) is important for promotion of somatic growth and the regulation of substrate metabolism. Metabolic action of GH occurs in multiple tissues including the liver, muscle, fat and pancreas either directly or indirectly through insulin-like growth factor 1. The diabetogenic action of GH has been well-described in previous in vivo studies. In this paper, we review the metabolic effects of GH on peripheral tissues focusing on glucose metabolism and insulin resistance, and discuss results from human studies on the long-term effects of GH administration on insulin resistance and hyperglycemia.

DrugBank Data that Cites this Article

Drugs

Somatotropin

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
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Acarbose Somatotropin	Somatotropin may decrease the hypoglycemic activities of Acarbose.
Acarbose Somatrem	Somatrem may decrease the hypoglycemic activities of Acarbose.
Acarbose Albusomatropin	Albusomatropin may decrease the hypoglycemic activities of Acarbose.
Acarbose Somatropin pegol	Somatropin pegol may decrease the hypoglycemic activities of Acarbose.
Acetohexamide Somatotropin	Somatotropin may decrease the hypoglycemic activities of Acetohexamide.