HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.
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Koller BH, Geraghty DE, Shimizu Y, DeMars R, Orr HT
HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.
J Immunol. 1988 Aug 1;141(3):897-904.
- PubMed ID
- 3260916 [ View in PubMed]
- Abstract
A MHC class I gene, HLA-6.2, has been identified. Examination of its primary structure indicates that HLA-6.2 is the most divergent member of the class I gene family characterized to date. Tissue distribution of HLA-6.2 RNA differs from other class I genes in that the highest level of RNA is detected in resting T lymphocytes. After transfer of the HLA-6.2 gene into a class I null human lymphoblastoid cell line, a protein associated with beta 2-microglobulin is detected. Analysis of HLA deletion mutant cell lines places the HLA-6.2 gene between the HLA-C and HLA-A loci on the short arm of chromosome 6. These data support the fact that the HLA-6.2 gene is a distinct expressible HLA class I gene, which we propose be designated HLA-E.