HLA class I histocompatibility antigen, alpha chain E

Details

Name
HLA class I histocompatibility antigen, alpha chain E
Synonyms
  • HLA-6.2
  • HLAE
  • MHC class I antigen E
Gene Name
HLA-E
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052599|HLA class I histocompatibility antigen, alpha chain E
MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND
AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH
GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY
LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ
DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ
PTIPIVGIIAGLVLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSESHSL
Number of residues
358
Molecular Weight
40057.305
Theoretical pI
Not Available
GO Classification
Functions
beta-2-microglobulin binding / MHC class I protein binding / natural killer cell lectin-like receptor binding / peptide antigen binding / signaling receptor binding / T cell receptor binding
Processes
adaptive immune response / antibacterial humoral response / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / antigen processing and presentation of exogenous peptide antigen via MHC class Ib / antigen processing and presentation of peptide antigen via MHC class I / CD8-positive, alpha-beta T cell activation / defense response to Gram-positive bacterium / innate immune response / interferon-gamma-mediated signaling pathway / natural killer cell tolerance induction / negative regulation of natural killer cell mediated cytotoxicity / positive regulation of antibody-dependent cellular cytotoxicity / positive regulation of CD8-positive, alpha-beta T cell activation / positive regulation of CD8-positive, alpha-beta T cell proliferation / positive regulation of immunoglobulin production / positive regulation of interleukin-13 production / positive regulation of interleukin-4 production / positive regulation of natural killer cell cytokine production / positive regulation of natural killer cell mediated cytotoxicity / positive regulation of natural killer cell mediated immunity / positive regulation of natural killer cell proliferation / positive regulation of T cell mediated cytotoxicity / positive regulation of TRAIL production / positive regulation of tumor necrosis factor production / protection from natural killer cell mediated cytotoxicity / regulation of immune response / regulation of natural killer cell mediated immunity / type I interferon signaling pathway / viral process
Components
cell surface / early endosome membrane / ER to Golgi transport vesicle membrane / external side of plasma membrane / extracellular exosome / extracellular space / Golgi membrane / integral component of lumenal side of endoplasmic reticulum membrane / MHC class I protein complex / MHC class Ib protein complex / phagocytic vesicle membrane / plasma membrane / recycling endosome membrane
General Function
Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334).
Specific Function
Beta-2-microglobulin binding
Pfam Domain Function
Transmembrane Regions
306-329
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052600|HLA class I histocompatibility antigen, alpha chain E (HLA-E)
ATGGTAGATGGAACCCTCCTTTTACTCCTCTCGGAGGCCCTGGCCCTTACCCAGACCTGG
GCGGGCTCCCACTCCTTGAAGTATTTCCACACTTCCGTGTCCCGGCCCGGCCGCGGGGAG
CCCCGCTTCATCTCTGTGGGCTACGTGGACGACACCCAGTTCGTGCGCTTCGACAACGAC
GCCGCGAGTCCGAGGATGGTGCCGCGGGCGCCGTGGATGGAGCAGGAGGGGTCAGAGTAT
TGGGACCGGGAGACACGGAGCGCCAGGGACACCGCACAGATTTTCCGAGTGAATCTGCGG
ACGCTGCGCGGCTACTACAATCAGAGCGAGGCCGGGTCTCACACCCTGCAGTGGATGCAT
GGCTGCGAGCTGGGGCCCGACGGGCGCTTCCTCCGCGGGTATGAACAGTTCGCCTACGAC
GGCAAGGATTATCTCACCCTGAATGAGGACCTGCGCTCCTGGACCGCGGTGGACACGGCG
GCTCAGATCTCCGAGCAAAAGTCAAATGATGCCTCTGAGGCGGAGCACCAGAGAGCCTAC
CTGGAAGACACATGCGTGGAGTGGCTCCACAAATACCTGGAGAAGGGGAAGGAGACGCTG
CTTCACCTGGAGCCCCCAAAGACACACGTGACTCACCACCCCATCTCTGACCATGAGGCC
ACCCTGAGGTGCTGGGCCCTGGGCTTCTACCCTGCGGAGATCACACTGACCTGGCAGCAG
GATGGGGAGGGCCATACCCAGGACACGGAGCTCGTGGAGACCAGGCCTGCAGGGGATGGA
ACCTTCCAGAAGTGGGCAGCTGTGGTGGTGCCTTCTGGAGAGGAGCAGAGATACACGTGC
CATGTGCAGCATGAGGGGCTACCCGAGCCCGTCACCCTGAGATGGAAGCCGGCTTCCCAG
CCCACCATCCCCATCGTGGGCATCATTGCTGGCCTGGTTCTCCTTGGATCTGTGGTCTCT
GGAGCTGTGGTTGCTGCTGTGATATGGAGGAAGAAGAGCTCAGGTGGAAAAGGAGGGAGC
TACTCTAAGGCTGAGTGGAGCGACAGTGCCCAGGGGTCTGAGTCTCACAGCTTGTAA
Chromosome Location
6
Locus
6p22.1
External Identifiers
ResourceLink
UniProtKB IDP13747
UniProtKB Entry NameHLAE_HUMAN
HGNC IDHGNC:4962
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails