Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling.
Article Details
- CitationCopy to clipboard
Feng Y, Wu H, Xu Y, Zhang Z, Liu T, Lin X, Feng XH
Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling.
J Biol Chem. 2014 Jan 24;289(4):2072-83. doi: 10.1074/jbc.M113.526905. Epub 2013 Dec 9.
- PubMed ID
- 24324267 [ View in PubMed]
- Abstract
ZNF451 is a transcriptional cofactor localized to promyelocytic leukemia bodies. Here, we present evidence demonstrating that ZNF451 physically interacts with Smad3/4 and functionally inhibits TGF-beta signaling. Increased expression of ZNF451 attenuates TGF-beta-induced growth inhibitory and gene transcriptional responses, whereas depletion of ZNF451 enhances TGF-beta responses. Mechanistically, ZNF451 blocks the ability of Smad3/4 to recruit p300 in response to TGF-beta, which causes reduction of histone H3K9 acetylation on the promoters of TGF-beta target genes. Taken together, ZNF451 acts as a transcriptional corepressor for Smad3/4 and negatively regulates TGF-beta signaling.