Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.
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Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y
Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11.
FEBS Lett. 1991 Jun 3;283(2):199-202. doi: 10.1016/0014-5793(91)80587-s.
- PubMed ID
- 1828438 [ View in PubMed]
- Abstract
A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open reading frame coding for an AGIF precursor of 199 amino acids. Analysis of the sequence of this cDNA revealed identity of this factor with a recently reported novel cytokine, designated interleukin-11 (IL-11). AGIF/IL-11 may play an important role in stromal cell-associated hematopoeisis through its regulatory action on adipocyte differentiation in the bone marrow microenvironment.