Interleukin-11

Details

Name

Interleukin-11

Synonyms

• Adipogenesis inhibitory factor
• AGIF
• IL-11

Gene Name

IL11

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052713|Interleukin-11
MNCVCRLVLVVLSLWPDTAVAPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQL
RDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLK
TLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGG
LHLTLDWAVRGLLLLKTRL

Number of residues

199

Molecular Weight

21428.87

Theoretical pI

Not Available

GO Classification

Functions

cytokine activity / growth factor activity / interleukin-11 receptor binding

Processes

B cell differentiation / fat cell differentiation / megakaryocyte differentiation / negative regulation of hormone secretion / positive regulation of cell population proliferation / positive regulation of MAPK cascade / positive regulation of peptidyl-serine phosphorylation / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of transcription by RNA polymerase II

Components

cytoplasm / extracellular region / extracellular space

General Function

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168).

Specific Function

Cytokine activity

Pfam Domain Function

• IL11 (PF07400)

Transmembrane Regions

Not Available

Cellular Location

Secreted

Gene sequence

>lcl|BSEQ0052714|Interleukin-11 (IL11)
ATGAACTGTGTTTGCCGCCTGGTCCTGGTCGTGCTGAGCCTGTGGCCAGATACAGCTGTC
GCCCCTGGGCCACCACCTGGCCCCCCTCGAGTTTCCCCAGACCCTCGGGCCGAGCTGGAC
AGCACCGTGCTCCTGACCCGCTCTCTCCTGGCGGACACGCGGCAGCTGGCTGCACAGCTG
AGGGACAAATTCCCAGCTGACGGGGACCACAACCTGGATTCCCTGCCCACCCTGGCCATG
AGTGCGGGGGCACTGGGAGCTCTACAGCTCCCAGGTGTGCTGACAAGGCTGCGAGCGGAC
CTACTGTCCTACCTGCGGCACGTGCAGTGGCTGCGCCGGGCAGGTGGCTCTTCCCTGAAG
ACCCTGGAGCCCGAGCTGGGCACCCTGCAGGCCCGACTGGACCGGCTGCTGCGCCGGCTG
CAGCTCCTGATGTCCCGCCTGGCCCTGCCCCAGCCACCCCCGGACCCGCCGGCGCCCCCG
CTGGCGCCCCCCTCCTCAGCCTGGGGGGGCATCAGGGCCGCCCACGCCATCCTGGGGGGG
CTGCACCTGACACTTGACTGGGCCGTGAGGGGACTGCTGCTGCTGAAGACTCGGCTGTGA

Chromosome Location

19

Locus

19q13.42

External Identifiers

Resource	Link
UniProtKB ID	P20809
UniProtKB Entry Name	IL11_HUMAN
HGNC ID	HGNC:5966

General References

1. Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O'Hara RM Jr, Leary AC, Sibley B, Clark SC, Williams DA, et al.: Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7512-6. doi: 10.1073/pnas.87.19.7512. [Article]
2. Kawashima I, Ohsumi J, Mita-Honjo K, Shimoda-Takano K, Ishikawa H, Sakakibara S, Miyadai K, Takiguchi Y: Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Lett. 1991 Jun 3;283(2):199-202. doi: 10.1016/0014-5793(91)80587-s. [Article]
3. McKinley D, Wu Q, Yang-Feng T, Yang YC: Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics. 1992 Jul;13(3):814-9. doi: 10.1016/0888-7543(92)90158-o. [Article]
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7. Harmegnies D, Wang XM, Vandenbussche P, Leon A, Vusio P, Grotzinger J, Jacques Y, Goormaghtigh E, Devreese B, Content J: Characterization of a potent human interleukin-11 agonist. Biochem J. 2003 Oct 1;375(Pt 1):23-32. doi: 10.1042/BJ20030459. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details