Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics.

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Nattrass M, Todd PG, Hinks L, Lloyd B, Alberti KG

Comparative effects of phenformin, metformin and glibenclamide on metabolic rhythms in maturity-onset diabetics.

Diabetologia. 1977 Apr;13(2):145-52.

PubMed ID

404205 [ View in PubMed

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Abstract

Twelve hour metabolic rhythms have been performed on six maturity-onset diabetic subjects during successive periods of therapy with phenformin, metformin, and glibenclamide. Moderate control of blood glucose concentration was achieved with phenformin and metformin, the lowest concentrations being found with glibenclamide. Mean blood lactate concentration was grossly elevated during phenformin therapy, moderately elevated with metformin and normal during glibenclamide treatment. Similar patterns were found for the lactate/pyruvate ratio, alanine, glycerol and ketone bodies. Serum triglyceride concentrations were significantly higher during phenformin treatment than with the other two regimes. Serum insulin concentration was higher on glibenclamide than with either biguanide. Most of these effects of the biguanides could be accounted for by an inhibitory effect on hepatic gluconeogenesis. It is concluded that the use of biguanides as hypoglycaemic agents in diabetes is associated with the production of multiple metabolic abnormalities.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Phenformin	Approved Investigational Withdrawn	Lactate	increased	Phenformin increases the level of Lactate in the blood