Improved oral glucose tolerance following antiserotonin treatment in patients with chemical diabetes.

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Ferrari C, Barbieri C, Caldara R, Magnoni V, Testori GP, Romussi M

Improved oral glucose tolerance following antiserotonin treatment in patients with chemical diabetes.

Eur J Clin Pharmacol. 1979 Jul;15(6):395-9.

PubMed ID

499287 [ View in PubMed

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Abstract

The effects of short-term treatment with either placebo or two serotonin antagonists, cyproheptadine and metergoline, on oral glucose tolerance and insulin secretion have been evaluated in normal subjects and in patients with chemical diabetes. Placebo treatment was not associated with any significant change in the parameters examined. Glucose tolerance in chemical diabetics was significantly improved both after cyproheptadine and metergoline; fasting plasma glucose was also reduced by metergoline. Treatment with the latter drug was also associated with a significant decrease in incremental glucose area in healthy subjects, which was not affected by cyproheptadine. Basal and glucose-stimulated insulin secretion were not affected by either drug in any subjects. Cyproheptadine and metergoline improve glucose metabolism in chemical diabetes probably by reducing insulin resistance. This may depend either on decreased secretion of counter-regulatory hormones or on a direct pharmacological action of the drugs on glucose utilization, possibly mediated by their common antiserotoninergic properties.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Metergoline	Approved	Glucose	decreased	Metergoline decreases the level of Glucose in the blood