Influence of methoxyflurane-nitrous oxide analgesia during childbirth on renal and hepatic function.

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Dahlgren BE

Influence of methoxyflurane-nitrous oxide analgesia during childbirth on renal and hepatic function.

Br J Anaesth. 1977 Dec;49(12):1271-7.

PubMed ID

588403 [ View in PubMed

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Abstract

Blood urea content and the serum concentrations of sodium, creatinine, uric acid, glutamic oxaloacetic transaminase (g.o.t.), glutamic pyruvate transaminase (g.p.t.) and bilirubin were measured before delivery, on the 2nd and 3rd days and on the 5th day after delivery. In two groups of mothers, one receiving nitrous oxide analgesia and the other a combination of nitrous oxide and methoxyflurane, blood urea and serum sodium and g.o.t. were increased following labour and nitrous oxide analgesia; s.g.p.t. was increased only in the late post-partum period. Serum sodium, creatinine, uric acid, urea, g.o.t. and g.p.t. increased following exposure to methoxyflurance. The increase in serum sodium, uric acid and urea was dose-dependent. Capillary concentrations of uric acid in the neonates showed dose-dependent changes in response to methoxyflurane.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Methoxyflurane	Approved Investigational Vet Approved Withdrawn	Sodium	increased	Methoxyflurane increases the level of Sodium in the blood
Methoxyflurane	Approved Investigational Vet Approved Withdrawn	Creatinine	increased	Methoxyflurane increases the level of Creatinine in the blood
Methoxyflurane	Approved Investigational Vet Approved Withdrawn	Uric acid	increased	Methoxyflurane increases the level of Uric acid in the blood
Methoxyflurane	Approved Investigational Vet Approved Withdrawn	Urea	increased	Methoxyflurane increases the level of Urea in the blood