Modulation of carcinoembryonic antigen release by HT-29 colon carcinoma line in the presence of different agents.
Article Details
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Friedman J, Seger M, Levinsky H, Allalouf D
Modulation of carcinoembryonic antigen release by HT-29 colon carcinoma line in the presence of different agents.
Experientia. 1987 Oct 15;43(10):1121-2. doi: 10.1007/BF01956058.
- PubMed ID
- 2444456 [ View in PubMed]
- Abstract
In this study we followed the effects of various differentiating agents on the expression of carcinoembryonic antigen (CEA) released into the medium by a colon carcinoma cell line HT-29. Butyric acid 1 mM markedly increased the level of CEA (12-fold in comparison to control levels). 12-O-tetradecanoyl-phorbol-13-acetate (TPA) 50 ng/ml and 5-azacytidine 4 x 10(-6) M increased the amount of CEA, 2- and 1.5-fold respectively. On the other hand retinoic acid 10(-5) M, N methyl-formamide 1% and N,N hexamethylene bisacetamide 2.5 mM decreased CEA 2-, 4- and 3-fold respectively. Our results emphasize that various differentiating agents affect CEA levels differently. Thus changes in CEA levels appear not to be reliable as a marker of a more differentiated phenotype.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tretinoin Carcinoembryonic antigen Protein Humans UnknownDownregulatorDetails