Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment.

Article Details

Citation
Copy to clipboard

Terao T, Minami Y

Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment.

Cells. 2019 Apr 3;8(4):312. doi: 10.3390/cells8040312.

PubMed ID
30987263 [ View in PubMed
]
Abstract

The Hedgehog (Hh) pathway, containing the Patched (PTCH) and Smoothened (SMO) multitransmembrane proteins, is the main regulator of vertebrate embryonic development. A non-canonical Hh pathway was recently observed in numerous types of solid cancers and hematological malignancies. Although acute myeloid leukemia (AML) is a common and lethal myeloid malignancy, the chemotherapy for AML has not changed in the last three decades. The Hh pathway and other intracellular signaling pathways are important for the tumor cells' cycle or therapeutic resistance of AML cells. In this article, we will review the current trends in Hh pathway inhibitors for treating AML.

DrugBank Data that Cites this Article

Drugs