Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata.
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Ramirez-Marin HA, Tosti A
Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata.
Drug Des Devel Ther. 2022 Feb 17;16:363-374. doi: 10.2147/DDDT.S334727. eCollection 2022.
- PubMed ID
- 35210753 [ View in PubMed]
- Abstract
Alopecia areata (AA) is an autoimmune condition that causes patchy hair loss, affecting up to 147 million people globally. Currently, there are no treatments approved by US Food and Drug Administration (FDA) specific for AA, and there are few effective therapeutic options for widespread and persistent illness. There is an ongoing need for a treatment that demonstrates a good clinical response with a benefit-risk ratio that is suitable for long-term use, especially for patients with chronic, extensive disease. Several clinical trials and case studies that have assessed Janus kinase inhibitors have had encouraging results. Ritlecitinib, a selective JAK3/TEC kinase inhibitor has been demonstrated to inhibit the action of signaling molecules and immune cells that are responsible for hair loss in people with alopecia areata. Furthermore, several clinical trials are investigating the utility of ritlecitinib in patients with vitiligo, rheumatoid arthritis, Crohn's disease, and ulcerative colitis. Advantages of using ritlecitinib when compared with other non-selective JAK inhibitors include avoiding JAK1/JAK2 inhibition's clinical repercussions, which include pharmacodynamic effects such as increased cholesterol and liver enzymes, and those related to JAK2 inhibition (thrombocytopenia, anemia). Treatment with Ritlecitinib 50 mg and 30 mg daily for 24 weeks has been shown to induce hair regrowth with a significant proportion of patients reaching SALT 20 (
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ritlecitinib Cytoplasmic tyrosine-protein kinase BMX Protein Humans YesInhibitorDetails Ritlecitinib Tyrosine-protein kinase BTK Protein Humans YesInhibitorDetails Ritlecitinib Tyrosine-protein kinase ITK/TSK Protein Humans YesInhibitorDetails Ritlecitinib Tyrosine-protein kinase JAK3 Protein Humans YesInhibitorDetails Ritlecitinib Tyrosine-protein kinase Tec Protein Humans YesInhibitorDetails Ritlecitinib Tyrosine-protein kinase TXK Protein Humans YesInhibitorDetails