Effect of cimetidine on plasma lipids and lipoproteins.

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Hoogwerf BJ, Grund VR, Hunninghake DB

Effect of cimetidine on plasma lipids and lipoproteins.

Clin Pharmacol Ther. 1984 Aug;36(2):217-20.

PubMed ID

6744780 [ View in PubMed

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Abstract

The effect of oral cimetidine on plasma lipid and lipoprotein levels was evaluated in a double-blind crossover study in 12 normal subjects and in 12 subjects with fasting serum glucose levels greater than or equal to 140 mg% or levels after a 100-gm oral glucose dose greater than or equal to 170 mg%. Plasma cholesterol (total, high-density, low-density, and very low-density lipoprotein) and triglyceride (total and very low-density lipoprotein) concentrations in placebo and cimetidine periods did not differ. Cimetidine was associated with elevated serum creatinine and aspartate amino transferase (SGOT) levels. One subject was impotent while on cimetidine.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Cimetidine	Approved Investigational	Creatinine	increased	Cimetidine increases the level of Creatinine in the blood