Effects of ethanol intake on lipoproteins.

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Brinton EA

Effects of ethanol intake on lipoproteins.

Curr Atheroscler Rep. 2012 Apr;14(2):108-14. doi: 10.1007/s11883-012-0230-7.

PubMed ID

22350634 [ View in PubMed

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Abstract

These review discusses the effects of ethanol on lipoprotein levels and function as related to atherosclerosis and cardiovascular disease (CVD), with special emphasis on recent publications. Ethanol's effects on high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), triglycerides (TG), and other CVD risk factors recently have been explored. Other new data address genetic and demographic predictors and mechanisms of these responses. Not surprisingly, the results of some recent studies corroborate, whereas others differ from, earlier seemingly well-established findings. Prior and recent evidence shows favorable changes in HDL, other CVD risk factors, and CVD event rates with moderate, regular ethanol intake, and recent publications have explored the mechanisms of this relationship. Application of these findings in clinical practice remains problematic, however, due to the lack of randomized, controlled clinical trials of ethanol and due to the potential hazards of ethanol consumption.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Ethanol	Approved	HDL cholesterol	increased	Ethanol increases the level of HDL cholesterol in the blood
Ethanol	Approved	HDL phospholipid	increased	Ethanol increases the level of HDL phospholipid in the blood
Ethanol	Approved	HDL polyunsaturated fatty acid	increased	Ethanol increases the level of HDL polyunsaturated fatty acid in the blood
Ethanol	Approved	triglycerides	increased	Ethanol increases the level of triglycerides in the blood
Ethanol	Approved	LDL cholesterol	increased	Ethanol increases the level of LDL cholesterol in the blood