Long-term carbon black inhalation induced the inflammation and autophagy of cerebellum in rats.

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Zhang H, Lou N, Liu XY, Li CZ, Xu K, Xu FF, Su AC, Zhang LY, Zhang M, Zhang JG

Long-term carbon black inhalation induced the inflammation and autophagy of cerebellum in rats.

Neurotoxicology. 2021 Dec;87:120-127. doi: 10.1016/j.neuro.2021.08.019. Epub 2021 Sep 9.

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34508789 [ View in PubMed
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Abstract

Carbon black (CB) has been demonstrated to have adverse effects on the lung tissue. Few studies explored the effects of CB on the cerebellum, widely recognized to contribute to gait and balance coordination and timing in the motor domain. Some studies have reported that inflammatory response and damaged autophagy are important mechanisms of CB toxicity and can be repaired after the recovery. The present study aimed to determine whether long-term CB exposure could induce the inflammation and damaged autophagy of the cerebellum. The rats were randomly divided into four groups. The control group received the filtered air for 90 days; the carbon black (CB) group received CB particles for 90 days; the recovery (R) group received CB for 90 days and recovered for another 14 days; the recovery control (RC) group received filtered air for 104 days. The purpose of the R group was to test whether neuroinflammation and autophagy could be repaired after short-term recovery. The western blot and immunohistochemistry revealed that long-term CB exposure induced augmented level of pro-inflammatory cytokines (Interleukin-1beta, IL-1beta; Interleukin-6, IL-6; and Tumor Necrosis Factor-alpha, TNF-alpha) and anti-inflammatory cytokine (Interleukin-10, IL-10). The autophagic markers (Beclin1 and LC3) were increased in both CB group and R group. These findings clearly demonstrated that long-term CB exposure induced inflammation and autophagy in the cerebellum, which were not obviously improved after short-term recovery.

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