Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.

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Feng S, Xia Y, Han D, Zheng C, He X, Tang X, Bai D

Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):523-6.

PubMed ID
15664805 [ View in PubMed
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Abstract

By targeting dual active sites of AChE, a number of new derivatives of HupB have been synthesized and tested as acetylcholinesterase inhibitors. The most potent compound, bis-HupB 5b is 72-fold more potent in AChE inhibition and 79-fold more selective for AChE versus BChE than HupB.

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