Huperzine B

DB03348ExperimentalSmall molecule

Huperzine B is a novel acetylcholinesterase inhibitor.

Mechanism: Huperzine B has been found to be an inhibitor of the enzyme acetylcholinesterase. This is the same mechanism of action of pharmaceutical drugs such as galantamine and donepezil used to treat Alzheimer's disease.
Curator reviewed
Primary indication: Under investigation for the treatment of Alzheimer's disease.Curator reviewed
Formula / weight: C₁₆H₂₀N₂O · 256.3428 g/mol (avg)
Also known as: HupB

Resolves to

Compound

Structure

InChIKeyYYWGABLTRMRUIT-HWWQOWPSSA-NSMILES[H][C@]12CCCN[C@]11CC(C)=C[C@H]2CC2=C1C=CC(=O)N2

Targets

What you can answer from here — as of September 13, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Huperzine B, and which of those have an active Phase 3 trial?

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