Manganese in health and disease.

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Avila DS, Puntel RL, Aschner M

Manganese in health and disease.

Met Ions Life Sci. 2013;13:199-227. doi: 10.1007/978-94-007-7500-8_7.

PubMed ID

24470093 [ View in PubMed

]

Abstract

Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.

DrugBank Data that Cites this Article

Drugs

Manganese cation

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Manganese cation	Glutamine synthetase	Protein	Humans	Unknown	Not Available	Details
Manganese cation	Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	Protein	Humans	Unknown	Cofactor	Details

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Manganese cation	Serotransferrin	Protein	Humans	Unknown	Binder	Details
Manganese cation	Serum albumin	Protein	Humans	Unknown	Binder	Details

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Manganese cation	Transient receptor potential cation channel subfamily M member 7	Protein	Humans	Unknown	Not Available	Details