Additive beneficial effects of atorvastatin combined with amlodipine in patients with mild-to-moderate hypertension.

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Koh KK, Quon MJ, Han SH, Lee Y, Park JB, Kim SJ, Koh Y, Shin EK

Additive beneficial effects of atorvastatin combined with amlodipine in patients with mild-to-moderate hypertension.

Int J Cardiol. 2011 Feb 3;146(3):319-25. doi: 10.1016/j.ijcard.2009.07.002. Epub 2009 Aug 3.

PubMed ID

19651449 [ View in PubMed

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Abstract

BACKGROUND: We hypothesized that atorvastatin combined with amlodipine has additive beneficial vascular and metabolic effects that are superior to monotherapy in patients with hypertension. METHODS: Forty-two patients were given atorvastatin 20mg/day and placebo, atorvastatin 20mg/day and amlodipine 10mg/day, or amlodipine 10mg/day and placebo during each 2-month treatment period of a randomized, single-blind, placebo-controlled cross-over trial with two 2-month washout periods. RESULTS: Atorvastatin combined with amlodipine or amlodipine alone significantly reduced blood pressure to a greater extent than atorvastatin alone (all P < 0.001 by ANOVA). Atorvastatin combined with amlodipine significantly reduced plasma malondialdehyde and improved flow-mediated dilation to a greater extent than atorvastatin or amlodipine alone (all P < 0.001 by ANOVA). Atorvastatin therapy significantly increased insulin levels (P = 0.004) and decreased plasma adiponectin levels (P = 0.016) and insulin sensitivity (determined by QUICKI; P = 0.026) relative to baseline measurements. Amlodipine therapy significantly decreased insulin levels (P = 0.001) and increased adiponectin levels (P < 0.001) and insulin sensitivity (P = 0.003) relative to baseline measurements. Atorvastatin combined with amlodipine therapy significantly increased adiponectin levels (P < 0.001) and insulin sensitivity (P = 0.034) relative to baseline measurements. Effects of all three therapeutic arms on adiponectin levels and insulin sensitivity were statistically significant (P < 0.001 by ANOVA). CONCLUSIONS: Atorvastatin combined with amlodipine therapy improves endothelial function and increases adiponectin levels and insulin sensitivity to a greater extent than monotherapy with either drug in hypertensive patients.

DrugBank Data that Cites this Article

Pharmaco-proteomics

Drug	Drug Groups	Gene	Gene ID	Change	Interaction	Chromosome
Amlodipine	Approved	INS	3630	decreased	Amlodipine results in decreased expression of INS protein	11p15.5
Atorvastatin	Approved	ADIPOQ	9370	decreased	Atorvastatin Calcium results in decreased expression of ADIPOQ protein	3q27.3
Atorvastatin	Approved	ADIPOQ	9370	increased	Atorvastatin Calcium results in increased expression of ADIPOQ protein	3q27.3
Atorvastatin	Approved	INS	3630	increased	Atorvastatin Calcium results in increased expression of INS protein	11p15.5