Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2.

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Rachid Z, Macphee M, Williams C, Todorova M, Jean-Claude BJ

Design and synthesis of new stabilized combi-triazenes for targeting solid tumors expressing the epidermal growth factor receptor (EGFR) or its closest homologue HER2.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5505-9. doi: 10.1016/j.bmcl.2009.05.060. Epub 2009 May 20.

PubMed ID

19665377 [ View in PubMed

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Abstract

The monoalkyltriazene moiety lends itself well to the design of combi-molecules. However, due to its instability under physiological conditions, efforts were directed towards stabilizing it by grafting a hydrolysable carbamate onto the 3-position. The synthesis and biological activities of these novel N-carbamyl triazenes are described.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Gefitinib	Epidermal growth factor receptor	IC 50 (nM)	33	N/A	N/A	Details