PPARgamma agonist from Chromolaena odorata.

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Zhang ML, Irwin D, Li XN, Sauriol F, Shi XW, Wang YF, Huo CH, Li LG, Gu YC, Shi QW

PPARgamma agonist from Chromolaena odorata.

J Nat Prod. 2012 Dec 28;75(12):2076-81. doi: 10.1021/np300386d. Epub 2012 Nov 27.

PubMed ID

23186307 [ View in PubMed

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Abstract

A phytochemical investigation of Chromolaena odorata resulted in the isolation of five new compounds, 5aalpha,6,9,9abeta,10-pentahydro-10beta-hydroxy-7-methylanthra[1,2-d][1,3]dioxol- 5-one (1), 1,2-methylenedioxy-6-methylanthraquinone (2), 3-hydroxy-1,2,4-trimethoxy-6-methylanthraquinone (3), 3-hydroxy-1,2-dimethoxy-6-methylanthraquinone (4), and 7-methoxy-7-epi-medioresinol (5), together with 12 known compounds, odoratin (6), 3beta-acetyloleanolic acid (7), ursolic acid (8), ombuin (9), 4,2'-dihydroxy-4',5',6'-trimethoxychalcone (10), (-)-pinoresinol (11), austrocortinin (12), tianshic acid (13), cleomiscosin D (14), (-)-medioresinol (15), (-)-syringaresinol (16), and cleomiscosin A (17). All the compounds were evaluated for their PPARgamma transactivation activity, and compound 6 showed moderate activity with an EC(50) value of 3.10 muM.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rosiglitazone	Peroxisome proliferator-activated receptor gamma	EC 50 (nM)	900	N/A	N/A	Details