Peroxisome proliferator-activated receptor gamma

BE0000215ProteinHumansPPARG

Ligand-activated transcription factor that forms obligate heterodimers with the retinoic acid receptor and acts as a key regulator of biological processes, such as adipocyte differentiation, lipid metabolism, glucose homeostasis and beta-oxidation of fatty acids (PubMed:16150867,... It is acted on by 121 drugs in DrugBank.

Gene name
PPARG
UniProtKB entry
P37231Swiss-Prot
Cellular location
Nucleus
Residues / weight
505 residues · 57,620 Da
Also known as
NR1C3 · Nuclear receptor subfamily 1 group C member 3 · PPAR-gamma

Resolves to

Protein
UniProtP37231UniProt namePPARG_HUMAN
Gene
HGNCHGNC:9236NCBI Gene5468GenBank1711117GeneCardsPPARG
Pharmacology
IUPHAR/GtoPdb595KEGGhsa:5468
Structure
PDB1FM6PDB1FM9PDB1I7I
Drugs

What you can answer from here — as of September 07, 2019

121DrugsApproved to experimental, with action, bond type and pharmacological action
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9Clinical trialsTrials of drugs acting on it, by phase and status
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74GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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355+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peroxisome proliferator-activated receptor gamma, how selective are they, and which programs against it are still in active trials?

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