3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.

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Castro JL, Street LJ, Guiblin AR, Jelley RA, Russell MG, Sternfeld F, Beer MS, Stanton JA, Matassa VG

3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.

J Med Chem. 1997 Oct 24;40(22):3497-500.

PubMed ID

9357514 [ View in PubMed

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Abstract

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DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Rizatriptan	5-hydroxytryptamine receptor 1B	IC 50 (nM)	41	N/A	N/A	Details
Rizatriptan	5-hydroxytryptamine receptor 1D	EC 50 (nM)	8.4	N/A	N/A	Details
Rizatriptan	5-hydroxytryptamine receptor 1D	IC 50 (nM)	11	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1B	IC 50 (nM)	16	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1D	EC 50 (nM)	16	N/A	N/A	Details
Sumatriptan	5-hydroxytryptamine receptor 1D	IC 50 (nM)	5	N/A	N/A	Details