1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.

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Gelmi ML, Caputo F, Clerici F, Pellegrino S, Giannaccini G, Betti L, Fabbrini L, Schmid L, Palego L, Lucacchini A

1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.

Bioorg Med Chem. 2007 Dec 15;15(24):7581-9. Epub 2007 Sep 12.

PubMed ID
17900912 [ View in PubMed
]
Abstract

Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
ParoxetineSodium-dependent serotonin transporterKi (nM)0.09N/AN/ADetails