Wake-promoting agents: search for next generation modafinil: part I.

Article Details

Citation

Dunn D, Hostetler G, Iqbal M, Messina-McLaughlin P, Reiboldt A, Lin YG, Gruner J, Bacon ER, Ator MA, Chatterjee S

Wake-promoting agents: search for next generation modafinil: part I.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2312-4. doi: 10.1016/j.bmcl.2011.12.099. Epub 2011 Dec 29.

PubMed ID
22264475 [ View in PubMed
]
Abstract

In search of a next generation molecule to the novel wake promoting agent modafinil, a series of bi-phenyl derived wakefulness enhancing agents (in rat) was developed. From this work, compound 17 has been selected for additional studies.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
ModafinilCytochrome P450 2C19IC 50 (nM)11000N/AN/ADetails