Wake-promoting agents: search for next generation modafinil: part I.

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Dunn D, Hostetler G, Iqbal M, Messina-McLaughlin P, Reiboldt A, Lin YG, Gruner J, Bacon ER, Ator MA, Chatterjee S

Wake-promoting agents: search for next generation modafinil: part I.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2312-4. doi: 10.1016/j.bmcl.2011.12.099. Epub 2011 Dec 29.

PubMed ID

22264475 [ View in PubMed

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Abstract

In search of a next generation molecule to the novel wake promoting agent modafinil, a series of bi-phenyl derived wakefulness enhancing agents (in rat) was developed. From this work, compound 17 has been selected for additional studies.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Modafinil	Cytochrome P450 2C19	IC 50 (nM)	11000	N/A	N/A	Details