Triterpenoid constituents isolated from the bark of Abies sachalinensis.
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Wada S, Iida A, Tanaka R
Triterpenoid constituents isolated from the bark of Abies sachalinensis.
J Nat Prod. 2002 Nov;65(11):1657-9.
- PubMed ID
- 12444693 [ View in PubMed]
- Abstract
Three new lanostane-type triterpenoids (1-3) were isolated from the bark of Abies sachalinensis along with a known compound (4). The structures of 1-4 were characterized by spectroscopic methods including NMR and MS. Compound 4 and some derivatives were tested for inhibitory effects on in vitro DNA topoisomerases I and II and found to be selective catalytic inhibitors of topoisomerase II activity with IC(50) values in the range 43-76 microM.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Etoposide DNA topoisomerase 2-alpha IC 50 (nM) 75700 N/A N/A Details