Triterpenoid constituents isolated from the bark of Abies sachalinensis.

Article Details

Citation

Copy to clipboard

Wada S, Iida A, Tanaka R

Triterpenoid constituents isolated from the bark of Abies sachalinensis.

J Nat Prod. 2002 Nov;65(11):1657-9.

PubMed ID

12444693 [ View in PubMed

]

Abstract

Three new lanostane-type triterpenoids (1-3) were isolated from the bark of Abies sachalinensis along with a known compound (4). The structures of 1-4 were characterized by spectroscopic methods including NMR and MS. Compound 4 and some derivatives were tested for inhibitory effects on in vitro DNA topoisomerases I and II and found to be selective catalytic inhibitors of topoisomerase II activity with IC(50) values in the range 43-76 microM.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Etoposide	DNA topoisomerase 2-alpha	IC 50 (nM)	75700	N/A	N/A	Details