Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.

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Davies TA, Page MG, Shang W, Andrew T, Kania M, Bush K

Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.

Antimicrob Agents Chemother. 2007 Jul;51(7):2621-4. Epub 2007 Apr 30.

PubMed ID

17470659 [ View in PubMed

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Abstract

Ceftobiprole exhibited tight binding to PBP2a in methicillin-resistant Staphylococcus aureus, PBP2x in penicillin-resistant Streptococcus pneumoniae, and PBP3 and other essential penicillin-binding proteins in methicillin-susceptible S. aureus, Escherichia coli, and Pseudomonas aeruginosa. Ceftobiprole also bound well to PBP2 in the latter organisms, contributing to the broad-spectrum antibacterial activity against gram-negative and gram-positive bacteria.

DrugBank Data that Cites this Article

Drugs

Ceftobiprole

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ceftobiprole	MecA	Protein	Staphylococcus aureus	Yes	Inhibitor	Details
Ceftobiprole	Penicillin-binding protein 2B	Protein	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	Yes	Inhibitor	Details
Ceftobiprole	Penicillin-binding protein 2x	Protein	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	Yes	Inhibitor	Details
Ceftobiprole	Peptidoglycan synthase FtsI	Protein	Escherichia coli (strain K12)	Unknown	Not Available	Details